生物合成工程實(shí)驗(yàn)室致力于代謝工程、合成生物學(xué)和分子生理學(xué)研究，已建立了成熟的大腸桿菌、畢赤酵母和鏈霉菌的遺傳操作平臺(tái)。與生物過(guò)程工程研究相補(bǔ)充和支持，構(gòu)建高效的細(xì)胞工廠，服務(wù)于工業(yè)生物技術(shù)、農(nóng)業(yè)生物技術(shù)、醫(yī)藥生物技術(shù)和環(huán)境生物技術(shù)等多個(gè)生物技術(shù)領(lǐng)域。
Our research work focuses on metabolic engineering, synthetic biology and molecular physiology on the basis of the well-established platforms for genetic manipulation of E. coli, P. pastoris and Streptomyces ssp.. Combined with the bioprocess engineering, we are harnessing the synthetic power of biology to build microbial cell factories for industrial, agricultural, medical, and environmental applications.


研究成果
1.GAP promoter library for fine-tuning gene expression in Pichia pastoris. Applied and Environmental Microbiology. 2011, 77: 3600-3608.
2.Reliable high-throughput approach for screening of engineered constitutive promoters in the yeast Pichia pastoris. Letters in Applied Microbiology. 2011, 52: 634-641.
3.Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination. Applied and Environmental Microbiology. 2011, 77: 7508-7516.
4.Progress in the research of S-adenosyl-L-methionine production. Applied Microbiology and Biotechnology. 2013, 97: 41-49.
5.Impacts of high β-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via 13C metabolic flux analysis. Journal of Biotechnology. 2014, 187: 124-134.
專利
1.GAP啟動(dòng)子文庫(kù)在調(diào)節(jié)S-腺苷甲硫氨酸代謝途徑中的應(yīng)用. 專利號(hào) ZL 201010621230.1
2.GAP啟動(dòng)子文庫(kù)及其用途. 專利號(hào) ZL 200910053198.9